当前位置:产品中心 > 抗体 > Biosimilar抗体 > TAA > Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)
Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)
基本信息

产品编号:GM-86372MAB

产品名称:Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)

目录价:询价


产品配图.jpg


规格货号

GM-86372MAB-1mg / 1 mg

GM-86372MAB-5mg / 5 mg

GM-86372MAB-25mg / 25 mg

GM-86372MAB-50mg / 50 mg

GM-86372MAB-100mg / 100mg


产品简介


Expression System      CHO

Aggregation                < 5% as determined by SEC-HPLC

Purity                           > 95% as determined by SDS-PAGE

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

Sterility                        0.2 μm Filtered

Target                          FOLR1

Clone                           Mirvetuximab

Alternative Names     FBP, FOLR, FRalpha, NCFTD

Source/Isotype           Monoclonal Human IgG1(KDEL,delta 447K), Kappa

Application                 ELISA

Description                 Folate receptor 1 (FOLR1), also known as folate receptor alpha and folate binding protein, is a glycosylphosphatidylinositol-linked protein, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

Formulation                phosphate-buffered solution, pH 7.4.


数据展示

SDS-PAGE

GM-86372MAB-1.png

On SDS-PAGE under reducing (R)/non-reducing(N-R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.



SEC-HPLC

GM-86372MAB-2.png


The purity of this product is more than 95% verified by SEC-HPLC



Indirect ELISA

/ueditor/image/20240516/1715836350730454/3d7f55a374488be9b720589898b810de.png


Human FOLR1 Protein; His Tag (Catalog # GM-84314RP) was immobilized at 1 μg/ml (100 μL/well). Increasing concentrations of Anti-FOLR1 hIgG1 Reference Antibody(Mirvebio) (Catalog # GM-86372MAB) were added.




当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)

Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)
基本信息

产品编号:GM-86372MAB

产品名称:Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)

目录价:询价


产品配图.jpg


规格货号

GM-86372MAB-1mg / 1 mg

GM-86372MAB-5mg / 5 mg

GM-86372MAB-25mg / 25 mg

GM-86372MAB-50mg / 50 mg

GM-86372MAB-100mg / 100mg


产品简介


Expression System      CHO

Aggregation                < 5% as determined by SEC-HPLC

Purity                           > 95% as determined by SDS-PAGE

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

Sterility                        0.2 μm Filtered

Target                          FOLR1

Clone                           Mirvetuximab

Alternative Names     FBP, FOLR, FRalpha, NCFTD

Source/Isotype           Monoclonal Human IgG1(KDEL,delta 447K), Kappa

Application                 ELISA

Description                 Folate receptor 1 (FOLR1), also known as folate receptor alpha and folate binding protein, is a glycosylphosphatidylinositol-linked protein, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

Formulation                phosphate-buffered solution, pH 7.4.


数据展示

SDS-PAGE

GM-86372MAB-1.png

On SDS-PAGE under reducing (R)/non-reducing(N-R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.



SEC-HPLC

GM-86372MAB-2.png


The purity of this product is more than 95% verified by SEC-HPLC



Indirect ELISA

/ueditor/image/20240516/1715836350730454/3d7f55a374488be9b720589898b810de.png


Human FOLR1 Protein; His Tag (Catalog # GM-84314RP) was immobilized at 1 μg/ml (100 μL/well). Increasing concentrations of Anti-FOLR1 hIgG1 Reference Antibody(Mirvebio) (Catalog # GM-86372MAB) were added.




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