2025-03-26 | IF=14.2994,Advanced Science,中国药科大学,AAV
"Genomeditech Biotechnology (Shanghai, China) constructed the adenoviruses. To specifically knock down Fis1 protein expression in the endothelium of ApoE−/− mice, adeno-associated virus serotype 9 (AAV9) carrying Fis1 shRNA driven by the endothelial-specific Tie2 promoter was used. The Fis1 shRNA targeting sequence was 5′CCTGATTGATAAGGCCATGAA-3′, and the control shRNA sequence was 5′-TTCTCCGAACGTGTCACGT-3′. tie2干扰AAV,内皮"