产品编号：GM-53165AB
产品名称：Anti-IL4R hIgG4 Antibody(Dupilumab)
目录价：询价
产品编号：GM-53165AB
产品名称：Anti-IL4R hIgG4 Antibody(Dupilumab)
目录价：询价
GM-53165AB-10 10 μg
GM-53165AB-100 100 μg
GM-53165AB-1000 1 mg
Species Reactivity Human; Cynomolgus
Clone Dupilumab
Source/Isotype Monoclonal Human hIgG4 /κ
Application Flow cytometry ;Block assay
Specificity Detects IL4R
Gene IL4R
Other Names CD124; IL4RA; IL-4RA
Gene ID 3566(human); 102133649(Cynomolgus)
Background The interleukin 4 receptor is a type I cytokine receptor. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
产品编号：GM-53165AB
产品名称：Anti-IL4R hIgG4 Antibody(Dupilumab)
目录价：询价
GM-53165AB-10 10 μg
GM-53165AB-100 100 μg
GM-53165AB-1000 1 mg
Species Reactivity Human; Cynomolgus
Clone Dupilumab
Source/Isotype Monoclonal Human hIgG4 /κ
Application Flow cytometry ;Block assay
Specificity Detects IL4R
Gene IL4R
Other Names CD124; IL4RA; IL-4RA
Gene ID 3566(human); 102133649(Cynomolgus)
Background The interleukin 4 receptor is a type I cytokine receptor. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
