产品编号：GM-87496MAB
产品名称：Anti-IL4R hIgG4 Reference Antibody (Dupbio)
目录价：询价
产品编号：GM-87496MAB
产品名称：Anti-IL4R hIgG4 Reference Antibody (Dupbio)
目录价：询价
GM-87496MAB-1mg / 1 mg
GM-87496MAB-5mg / 5 mg
GM-87496MAB-25mg / 25 mg
GM-87496MAB-50mg / 50mg
GM-87496MAB-100mg / 100 mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target IL4R
Clone Dupilumab
Alternative Names CD124; IL4RA; IL-4RA
Source/Isotype Human IgG4(S228P), Kappa
Application /
Description The interleukin 4 receptor is a type I cytokine receptor. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
Formulation Phosphate-buffered solution, pH 7.4.
产品编号：GM-87496MAB
产品名称：Anti-IL4R hIgG4 Reference Antibody (Dupbio)
目录价：询价
GM-87496MAB-1mg / 1 mg
GM-87496MAB-5mg / 5 mg
GM-87496MAB-25mg / 25 mg
GM-87496MAB-50mg / 50mg
GM-87496MAB-100mg / 100 mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target IL4R
Clone Dupilumab
Alternative Names CD124; IL4RA; IL-4RA
Source/Isotype Human IgG4(S228P), Kappa
Application /
Description The interleukin 4 receptor is a type I cytokine receptor. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
Formulation Phosphate-buffered solution, pH 7.4.
