当前位置:产品中心 > 抗体 > Biosimilar抗体 > 细胞因子 > Anti-IL4R hIgG4 Antibody(Dupilumab)
Anti-IL4R hIgG4 Antibody(Dupilumab)
基本信息

产品编号:GM-53165AB

产品名称:Anti-IL4R hIgG4 Antibody(Dupilumab)

目录价:询价

产品配图.jpg


规格货号

GM-53165AB-10        10 μg

GM-53165AB-100      100 μg

GM-53165AB-1000    1 mg


产品简介

Species Reactivity     Human; Cynomolgus

Clone                          Dupilumab

Source/Isotype          Monoclonal Human hIgG4 /κ

Application                Flow cytometry ;Block assay

Specificity                  Detects IL4R

Gene                           IL4R

Other Names             CD124; IL4RA; IL-4RA

Gene ID                      3566(human); 102133649(Cynomolgus)

Background               The interleukin 4 receptor is a type I cytokine receptor. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among  T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.

Storage                       Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation               Phosphate-buffered solution, pH 7.2.

Endotoxin                   < 1 EU/mg, determined by LAL gel clotting assay



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当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-IL4R hIgG4 Antibody(Dupilumab)

Anti-IL4R hIgG4 Antibody(Dupilumab)
基本信息

产品编号:GM-53165AB

产品名称:Anti-IL4R hIgG4 Antibody(Dupilumab)

目录价:询价

产品配图.jpg


规格货号

GM-53165AB-10        10 μg

GM-53165AB-100      100 μg

GM-53165AB-1000    1 mg


产品简介

Species Reactivity     Human; Cynomolgus

Clone                          Dupilumab

Source/Isotype          Monoclonal Human hIgG4 /κ

Application                Flow cytometry ;Block assay

Specificity                  Detects IL4R

Gene                           IL4R

Other Names             CD124; IL4RA; IL-4RA

Gene ID                      3566(human); 102133649(Cynomolgus)

Background               The interleukin 4 receptor is a type I cytokine receptor. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among  T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.

Storage                       Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation               Phosphate-buffered solution, pH 7.2.

Endotoxin                   < 1 EU/mg, determined by LAL gel clotting assay



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