| Expression System | CHO |
| Aggregation | < 5% as determined by SEC-HPLC |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Sterility | 0.2 μm Filtered |
| Target | VEGFR-2 |
| Clone | DC101 |
| Other Names | 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR2, orv, sVEGFR-2 |
| Source/Isotype | Monoclonal Rat IgG1, κ |
| Application | / |
| Description | VEGFR-2, also known as KDR (kinase insertion domain receptor) and Flk-1 in mice, is the main receptor mediating the angiogenic response to vascular endothelial growth factor (VEGF). DC101 is a monoclonal antibody targeting mouse VEGFR-2, and its core mechanism is to inhibit VEGFR-2 signaling by specifically blocking VEGF binding to VEGFR-2, which can be used to inhibit VEGFR-2 signaling, it can inhibit tumor angiogenesis, tumor proliferation and metastasis, and affect the activity of cancer stem cells (CSCs) and tumor immune microenvironment. |
| Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
| Expression System | CHO |
| Aggregation | < 5% as determined by SEC-HPLC |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Sterility | 0.2 μm Filtered |
| Target | VEGFR-2 |
| Clone | DC101 |
| Other Names | 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR2, orv, sVEGFR-2 |
| Source/Isotype | Monoclonal Rat IgG1, κ |
| Application | / |
| Description | VEGFR-2, also known as KDR (kinase insertion domain receptor) and Flk-1 in mice, is the main receptor mediating the angiogenic response to vascular endothelial growth factor (VEGF). DC101 is a monoclonal antibody targeting mouse VEGFR-2, and its core mechanism is to inhibit VEGFR-2 signaling by specifically blocking VEGF binding to VEGFR-2, which can be used to inhibit VEGFR-2 signaling, it can inhibit tumor angiogenesis, tumor proliferation and metastasis, and affect the activity of cancer stem cells (CSCs) and tumor immune microenvironment. |
| Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
