产品编号：GM-87351MAB
产品名称：Anti-FcRn hIgG4 Reference Antibody(Rozabio)
目录价：询价
产品编号：GM-87351MAB
产品名称：Anti-FcRn hIgG4 Reference Antibody(Rozabio)
目录价：询价
GM-87351MAB-1mg / 1 mg
GM-87351MAB-5mg / 5 mg
GM-87351MAB-25mg / 25 mg
GM-87351MAB-50mg / 50mg
GM-87351MAB-100mg / 100 mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target FcRn
Clone Rozanolixizumab
Alternative Names FCGRT, FcgammaRn, alpha-chain
Source/Isotype Human IgG4(S228P), Kappa
Application /
Description The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. In rodents, FcRn was originally identified as the receptor that transports maternal immunoglobulin G (IgG) from mother to neonatal offspring via mother's milk, leading to its name as the neonatal Fc receptor. In humans, FcRn is present in the placenta where it transports mother's IgG to the growing fetus. FcRn has also been shown to play a role in regulating IgG and serum albumin turnover. Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine, TNF-α, and down-regulated by IFN-γ.
Formulation Phosphate-buffered solution, pH 7.4.
产品编号：GM-87351MAB
产品名称：Anti-FcRn hIgG4 Reference Antibody(Rozabio)
目录价：询价
GM-87351MAB-1mg / 1 mg
GM-87351MAB-5mg / 5 mg
GM-87351MAB-25mg / 25 mg
GM-87351MAB-50mg / 50mg
GM-87351MAB-100mg / 100 mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target FcRn
Clone Rozanolixizumab
Alternative Names FCGRT, FcgammaRn, alpha-chain
Source/Isotype Human IgG4(S228P), Kappa
Application /
Description The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. In rodents, FcRn was originally identified as the receptor that transports maternal immunoglobulin G (IgG) from mother to neonatal offspring via mother's milk, leading to its name as the neonatal Fc receptor. In humans, FcRn is present in the placenta where it transports mother's IgG to the growing fetus. FcRn has also been shown to play a role in regulating IgG and serum albumin turnover. Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine, TNF-α, and down-regulated by IFN-γ.
Formulation Phosphate-buffered solution, pH 7.4.
