产品编号：GM-87935AB
产品名称：Anti-H_TSHR mIgG2a Antibody(KSAb2)
目录价：询价
产品编号：GM-87935AB
产品名称：Anti-H_TSHR mIgG2a Antibody(KSAb2)
目录价：询价
GM-87935AB-10 10 μg
GM-87935AB-100 100 μg
GM-87935AB-1000 1 mg
Species Reactivity Human
Clone KSAb2
Source/Isotype Monoclonal mIgG2a/κ
Application Flow cytometry
Specificity Detects TSHR
Gene TSHR
Other Names CHNG1, LGR3, hTSHR-I
Gene ID 7253 (human)
Background The TSHR (Thyroid Stimulating Hormone Receptor) gene encodes a transmembrane G protein-coupled receptor essential for thyroid function regulation. Expressed on thyroid follicular cell membranes, it binds TSH to activate signaling pathways like cAMP-PKA, controlling thyroid hormone (T3 and T4) synthesis and maintaining metabolic and endocrine balance.TSHR antibodies (TSHR-Ab) are highly specific tools for studying TSHR function and thyroid disease mechanisms. In Graves' disease, stimulatory antibodies (TSAb) mimic TSH, overactivating TSHR and causing excessive hormone secretion, while blocking antibodies (TBAb) inhibit TSH binding, leading to hypothyroidism. TSHR antibodies are valuable in disease diagnosis, drug development, and animal model construction, supporting thyroid disease research and clinical applications.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
产品编号：GM-87935AB
产品名称：Anti-H_TSHR mIgG2a Antibody(KSAb2)
目录价：询价
GM-87935AB-10 10 μg
GM-87935AB-100 100 μg
GM-87935AB-1000 1 mg
Species Reactivity Human
Clone KSAb2
Source/Isotype Monoclonal mIgG2a/κ
Application Flow cytometry
Specificity Detects TSHR
Gene TSHR
Other Names CHNG1, LGR3, hTSHR-I
Gene ID 7253 (human)
Background The TSHR (Thyroid Stimulating Hormone Receptor) gene encodes a transmembrane G protein-coupled receptor essential for thyroid function regulation. Expressed on thyroid follicular cell membranes, it binds TSH to activate signaling pathways like cAMP-PKA, controlling thyroid hormone (T3 and T4) synthesis and maintaining metabolic and endocrine balance.TSHR antibodies (TSHR-Ab) are highly specific tools for studying TSHR function and thyroid disease mechanisms. In Graves' disease, stimulatory antibodies (TSAb) mimic TSH, overactivating TSHR and causing excessive hormone secretion, while blocking antibodies (TBAb) inhibit TSH binding, leading to hypothyroidism. TSHR antibodies are valuable in disease diagnosis, drug development, and animal model construction, supporting thyroid disease research and clinical applications.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
