细胞因子（cytokine，CK）是免疫原、丝裂原或其他刺激剂诱导多种细胞产生的低分子量可溶性蛋白质，具有调节固有免疫和适应性免疫、血细胞生成、细胞生长、APSC多能细胞以及损伤组织修复等多种功能。细胞因子可被分为白细胞介素、干扰素、肿瘤坏死因子超家族、集落刺激因子、趋化因子、生长因子等。多细胞因子在体内通过旁分泌、自分泌或内分泌等方式发挥作用，具有多效性、重叠性、拮抗性、协同性等多种生理特性，形成了十分复杂的细胞因子调节网络，参与人体多种重要的生理功能。
细胞因子在免疫细胞的发育分化、免疫应答及免疫调节过程中都具有重要作用，但它也是把“双刃剑”，在一定条件下可参与多种疾病的发生。例如，在免疫应答时，免疫细胞分泌大量的细胞因子，细胞因子又刺激免疫细胞，这样的正反馈调节如果失灵，就会引起“细胞因子风暴”。“细胞因子风暴”可发生在多种疾病，如急性呼吸窘迫综合征、SARS（重症急性呼吸综合征）和流感等。
| 靶点 | 产品货号 | 产品名称 |
|
TGF-β
|
GM-82350AB
|
Anti-ACVR2B hIgG1 Antibody(Fab-17G05)
|
|
TGF-β
|
GM-81622AB
|
Anti-ITGB6 hIgG1 Antibody(SGN-B6A)
|
|
TGF-β
|
GM-87349MAB
|
Anti-H_ITGB6 hIgG1 Reference Antibody（h2A2）
|
|
TGF-β
|
GM-53193AB
|
Anti-αvβ6 hIgG1 Antibody(m15H3)
|
|
TGF-β
|
GM-51148AB
|
Anti-ACVR2B hIgG1 Antibody(Bimagrumab)
|
|
TGF-β
|
GM-30474AB
|
Anti-GARP-TGF-β1 hIgG4 Antibody(ARGX-115)
|
|
TGF-β
|
GM-26831AB
|
Anti-TGFB1 hIgG4 Antibody(SRK-181)
|
|
TGF-β
|
GM-49298AB
|
Anti-αv hIgG2 Antibody(Abituzumab)
|
|
TGF-β
|
GM-86367MAB
|
Anti-H_ACVR2B hIgG1 Reference Antibody(Bimbio)
|
|
VEGF
|
GM-87758MAB
|
Anti-VEGF hIgG1 Reference Antibody (Bevbio)
|
|
VEGF
|
GM-51978AB
|
Anti-VEGF hIgG1 Antibody(Bevacizumab)
|
|
GDF15
|
GM-71274AB
|
Anti-H_GDF15 hIgG4 Antibody(CTL-002)
|
|
GDF15
|
GM-87500MAB
|
Anti-GDF15 hIgG1 Reference Antibody(Ponsbio)
|
|
GDF15
|
GM-71276AB
|
Anti-H_GFRAL hIgG4 Antibody(QUEL-0301)
|
|
IL-12
|
GM-46333AB
|
Anti-IL-12/23(p40) hIgG1 antibody(Ustekinumab)
|
|
IL-7
|
GM-52274AB
|
Anti-IL7Ra hIgG1 Antibody(4A10)
|
|
IL-11
|
GM-57288AB
|
Anti-IL-11 hIgG4 Antibody(Hu16E12)
|
|
IL-11RA
|
GM-57287AB
|
Anti-IL-11RA hIgG1 Antibody(58B10-9C3-4E5)
|
|
IL-4
|
GM-53165AB
|
Anti-IL4R hIgG4 Antibody（Dupilumab）
|
|
IL-4
|
GM-46268AB
|
Anti-IL-4R hIgG1 Antibody(12B5)
|
|
IL4R
|
GM-87496MAB
|
Anti-IL4R hIgG4 Reference Antibody (Dupbio)
|
|
CTGF(CCN2):aVb3
|
GM-51125AB
|
Anti-ITGB3 hIgG1 Antibody(etaracizumab)
|
|
CTGF(CCN2):aVb3
|
GM-51031AB
|
Anti-CTGF hIgG1 Antibody(Pamrevlumab)
|
|
IL-31
|
GM-50883AB
|
Anti-IL31 hIgG1 Antibody(mAb33)
|
|
IL-31
|
GM-50874AB
|
Anti-OSMR hIgG4 Antibody(Vixarelimab)
|
|
IL-33
|
GM-31628AB
|
Anti-IL33 hIgG4 Antibody(Itepekimab)
|
|
IL-33
|
GM-87354MAB
|
Anti-IL33 hIgG4 ReferenceAntibody (Itepbio)
|
|
IL-2
|
GM-52319AB
|
Anti-CD122 hIgG1 Antibody（HuABC-2）
|
|
IL-5
|
GM-52408AB
|
Anti-IL5 hIgG4 Antibody(Reslizumab)
|
|
IL-5
|
GM-46851AB
|
Anti-IL-5R hIgG1 Antibody(Benralizumab)
|
|
IL-2
|
GM-52334AB
|
Anti-CD132(IL2RG) hIgG4 Antibody(REGN7257)
|
|
IL-2
|
GM-52329AB
|
Anti-CD25 hIgG1 Antibody(Basiliximab)
|
|
IL-1
|
GM-51990AB
|
Anti-IL1R1 hIgG1 Antibody(AMG 108)
|
|
IL-1β
|
GM-51764AB
|
Anti-IL-1β hIgG1 Antibody(Canakinumab)
|
|
IL-31
|
GM-50880AB
|
Anti-IL31RA hIgG1 Antibody(NA633)
|
|
IL-31
|
GM-50871AB
|
Anti-IL31RA hIgG2 Antibody(Nemolizumab)
|
|
IL-17
|
GM-27267AB
|
Anti-IL-17A hIgG1 Antibody(Secukinumab)
|
|
IL-17A
|
GM-87353MAB
|
Anti-IL17A hIgG1 Reference Antibody (Secubio)
|
|
PRL-PRLR
|
GM-27198AB
|
Anti-PRLR hIgG1 Antibody(Mat3)
|
|
PRLR
|
GM-87347MAB
|
Anti-PRLR hIgG1 Reference Antibody(Mat3)
|
|
IL-22
|
GM-46509AB
|
Anti-H_IL-22 hIgG1 Antibody(Fezakinumab)
|
|
IL-22
|
GM-46382AB
|
Anti-H_IL-22R1 hIgG1 Antibody(ARGX-112)
|
|
TGF-β
|
GM-87700AB
|
Anti-ACVR2B mIgG2a Antibody(Bimagrumab)
|
|
IGF-1R
|
GM-87441AB
|
Anti-IGF-1R hIgG1 Antibody(teprotumumab）
|
|
NPR1
|
GM-87696AB
|
Anti-NPR1 hIgG1 Antibody(XX-16)
|
|
NPR1
|
GM-87697AB
|
Anti-NPR1 hIgG4 Antibody(REGN-5381)
|
|
RANKL
|
GM-77688AB
|
Anti-H_RANKL hIgG2 Antibody(Denosumab)
|
|
IL-23R
|
GM-87786AB
|
Anti-IL-23R hIgG1 Antibody(5D4)
|
| 靶点 | 产品货号 | 产品名称 |
|
TGF-β
|
GM-82350AB
|
Anti-ACVR2B hIgG1 Antibody(Fab-17G05)
|
|
TGF-β
|
GM-81622AB
|
Anti-ITGB6 hIgG1 Antibody(SGN-B6A)
|
|
TGF-β
|
GM-87349MAB
|
Anti-H_ITGB6 hIgG1 Reference Antibody（h2A2）
|
|
TGF-β
|
GM-53193AB
|
Anti-αvβ6 hIgG1 Antibody(m15H3)
|
|
TGF-β
|
GM-51148AB
|
Anti-ACVR2B hIgG1 Antibody(Bimagrumab)
|
|
TGF-β
|
GM-30474AB
|
Anti-GARP-TGF-β1 hIgG4 Antibody(ARGX-115)
|
|
TGF-β
|
GM-26831AB
|
Anti-TGFB1 hIgG4 Antibody(SRK-181)
|
|
TGF-β
|
GM-49298AB
|
Anti-αv hIgG2 Antibody(Abituzumab)
|
|
TGF-β
|
GM-86367MAB
|
Anti-H_ACVR2B hIgG1 Reference Antibody(Bimbio)
|
|
VEGF
|
GM-87758MAB
|
Anti-VEGF hIgG1 Reference Antibody (Bevbio)
|
|
VEGF
|
GM-51978AB
|
Anti-VEGF hIgG1 Antibody(Bevacizumab)
|
|
GDF15
|
GM-71274AB
|
Anti-H_GDF15 hIgG4 Antibody(CTL-002)
|
|
GDF15
|
GM-87500MAB
|
Anti-GDF15 hIgG1 Reference Antibody(Ponsbio)
|
|
GDF15
|
GM-71276AB
|
Anti-H_GFRAL hIgG4 Antibody(QUEL-0301)
|
|
IL-12
|
GM-46333AB
|
Anti-IL-12/23(p40) hIgG1 antibody(Ustekinumab)
|
|
IL-7
|
GM-52274AB
|
Anti-IL7Ra hIgG1 Antibody(4A10)
|
|
IL-11
|
GM-57288AB
|
Anti-IL-11 hIgG4 Antibody(Hu16E12)
|
|
IL-11RA
|
GM-57287AB
|
Anti-IL-11RA hIgG1 Antibody(58B10-9C3-4E5)
|
|
IL-4
|
GM-53165AB
|
Anti-IL4R hIgG4 Antibody（Dupilumab）
|
|
IL-4
|
GM-46268AB
|
Anti-IL-4R hIgG1 Antibody(12B5)
|
|
IL4R
|
GM-87496MAB
|
Anti-IL4R hIgG4 Reference Antibody (Dupbio)
|
|
CTGF(CCN2):aVb3
|
GM-51125AB
|
Anti-ITGB3 hIgG1 Antibody(etaracizumab)
|
|
CTGF(CCN2):aVb3
|
GM-51031AB
|
Anti-CTGF hIgG1 Antibody(Pamrevlumab)
|
|
IL-31
|
GM-50883AB
|
Anti-IL31 hIgG1 Antibody(mAb33)
|
|
IL-31
|
GM-50874AB
|
Anti-OSMR hIgG4 Antibody(Vixarelimab)
|
|
IL-33
|
GM-31628AB
|
Anti-IL33 hIgG4 Antibody(Itepekimab)
|
|
IL-33
|
GM-87354MAB
|
Anti-IL33 hIgG4 ReferenceAntibody (Itepbio)
|
|
IL-2
|
GM-52319AB
|
Anti-CD122 hIgG1 Antibody（HuABC-2）
|
|
IL-5
|
GM-52408AB
|
Anti-IL5 hIgG4 Antibody(Reslizumab)
|
|
IL-5
|
GM-46851AB
|
Anti-IL-5R hIgG1 Antibody(Benralizumab)
|
|
IL-2
|
GM-52334AB
|
Anti-CD132(IL2RG) hIgG4 Antibody(REGN7257)
|
|
IL-2
|
GM-52329AB
|
Anti-CD25 hIgG1 Antibody(Basiliximab)
|
|
IL-1
|
GM-51990AB
|
Anti-IL1R1 hIgG1 Antibody(AMG 108)
|
|
IL-1β
|
GM-51764AB
|
Anti-IL-1β hIgG1 Antibody(Canakinumab)
|
|
IL-31
|
GM-50880AB
|
Anti-IL31RA hIgG1 Antibody(NA633)
|
|
IL-31
|
GM-50871AB
|
Anti-IL31RA hIgG2 Antibody(Nemolizumab)
|
|
IL-17
|
GM-27267AB
|
Anti-IL-17A hIgG1 Antibody(Secukinumab)
|
|
IL-17A
|
GM-87353MAB
|
Anti-IL17A hIgG1 Reference Antibody (Secubio)
|
|
PRL-PRLR
|
GM-27198AB
|
Anti-PRLR hIgG1 Antibody(Mat3)
|
|
PRLR
|
GM-87347MAB
|
Anti-PRLR hIgG1 Reference Antibody(Mat3)
|
|
IL-22
|
GM-46509AB
|
Anti-H_IL-22 hIgG1 Antibody(Fezakinumab)
|
|
IL-22
|
GM-46382AB
|
Anti-H_IL-22R1 hIgG1 Antibody(ARGX-112)
|
|
TGF-β
|
GM-87700AB
|
Anti-ACVR2B mIgG2a Antibody(Bimagrumab)
|
|
IGF-1R
|
GM-87441AB
|
Anti-IGF-1R hIgG1 Antibody(teprotumumab）
|
|
NPR1
|
GM-87696AB
|
Anti-NPR1 hIgG1 Antibody(XX-16)
|
|
NPR1
|
GM-87697AB
|
Anti-NPR1 hIgG4 Antibody(REGN-5381)
|
|
RANKL
|
GM-77688AB
|
Anti-H_RANKL hIgG2 Antibody(Denosumab)
|
|
IL-23R
|
GM-87786AB
|
Anti-IL-23R hIgG1 Antibody(5D4)
|
细胞因子（cytokine，CK）是免疫原、丝裂原或其他刺激剂诱导多种细胞产生的低分子量可溶性蛋白质，具有调节固有免疫和适应性免疫、血细胞生成、细胞生长、APSC多能细胞以及损伤组织修复等多种功能。细胞因子可被分为白细胞介素、干扰素、肿瘤坏死因子超家族、集落刺激因子、趋化因子、生长因子等。多细胞因子在体内通过旁分泌、自分泌或内分泌等方式发挥作用，具有多效性、重叠性、拮抗性、协同性等多种生理特性，形成了十分复杂的细胞因子调节网络，参与人体多种重要的生理功能。
细胞因子在免疫细胞的发育分化、免疫应答及免疫调节过程中都具有重要作用，但它也是把“双刃剑”，在一定条件下可参与多种疾病的发生。例如，在免疫应答时，免疫细胞分泌大量的细胞因子，细胞因子又刺激免疫细胞，这样的正反馈调节如果失灵，就会引起“细胞因子风暴”。“细胞因子风暴”可发生在多种疾病，如急性呼吸窘迫综合征、SARS（重症急性呼吸综合征）和流感等。
