当前位置:产品中心 > 抗体 > Biosimilar抗体 > 免疫检查点 > Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab)
Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab)
基本信息

产品编号:GM-31740AB

产品名称:Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab)

目录价:询价


产品配图.jpg

规格货号

GM-31740AB-10           10 μg

GM-31740AB-100         100 μg

GM-31740AB-1000       1mg

产品简介

Species Reactivity      Human; Mouse

Clone                           Atezolizumab

Source/Isotype           Monoclonal Human IgG1 /κ

Application                 Flow Cytometry; Block assay

Specificity                   Detects PDL1

Gene                            PDL1

Other Names              B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, CD274, hPD-L1

Gene ID                       29126(human), 60533(mouse)

Background                Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the adaptive immune system reacts to antigens that are associated with immune system activation by exogenous or endogenous danger signals. In turn, clonal expansion of antigen-specific CD8+ T cells and/or CD4+ helper cells is propagated. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

数据展示

/ueditor/image/20240524/1716531430904262/7a48a44ccb3099c2226a6eae98d67a34.png

/ueditor/image/20240524/1716531446217039/58eac09ff6cc61a3bee2f5ab02f38645.png

/ueditor/image/20240524/1716531462187014/a5c9b19d2ea616a650b83e83d6802513.png

当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab)

Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab)
基本信息

产品编号:GM-31740AB

产品名称:Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab)

目录价:询价


产品配图.jpg

规格货号

GM-31740AB-10           10 μg

GM-31740AB-100         100 μg

GM-31740AB-1000       1mg

产品简介

Species Reactivity      Human; Mouse

Clone                           Atezolizumab

Source/Isotype           Monoclonal Human IgG1 /κ

Application                 Flow Cytometry; Block assay

Specificity                   Detects PDL1

Gene                            PDL1

Other Names              B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, CD274, hPD-L1

Gene ID                       29126(human), 60533(mouse)

Background                Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the adaptive immune system reacts to antigens that are associated with immune system activation by exogenous or endogenous danger signals. In turn, clonal expansion of antigen-specific CD8+ T cells and/or CD4+ helper cells is propagated. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

数据展示

/ueditor/image/20240524/1716531430904262/7a48a44ccb3099c2226a6eae98d67a34.png

/ueditor/image/20240524/1716531446217039/58eac09ff6cc61a3bee2f5ab02f38645.png

/ueditor/image/20240524/1716531462187014/a5c9b19d2ea616a650b83e83d6802513.png

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