当前位置:产品中心 > 抗体 > Biosimilar抗体 > 免疫检查点 > Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab)
Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab)
基本信息

产品编号:GM-27203AB

产品名称:Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab) 

目录价:询价


产品配图.jpg

规格货号

GM-27203AB-10           10 μg

GM-27203AB-100         100 μg

GM-27203AB-1000       1mg

产品简介

Species Reactivity      Human; Cynomolgus

Clone                           Ipilimumab

Source/Isotype           Monoclonal Human IgG1 /κ

Application                 Flow Cytometry; Bioassay

Specificity                   Detects CTLA-4

Gene                            CTLA-4

Other Names              ALPS5, CD, CD152, CELIAC3, CTLA4, GRD4, GSE, IDDM12

Gene ID                       1493(human); G7PL88-1(Cynomolgus)

Background                CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. CTLA-4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA-4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. CTLA-4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

数据展示

/ueditor/image/20240527/1716775556306375/9bb994d4a5c8b0352ddc40613bd07dfc.png


/ueditor/image/20240527/1716775577580611/dbecf170a5cd6071570c5058f085261e.png


/ueditor/image/20240527/1716775599114006/6cf0348da4666ef1a394b494ac8429b7.png

当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab)

Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab)
基本信息

产品编号:GM-27203AB

产品名称:Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab) 

目录价:询价


产品配图.jpg

规格货号

GM-27203AB-10           10 μg

GM-27203AB-100         100 μg

GM-27203AB-1000       1mg

产品简介

Species Reactivity      Human; Cynomolgus

Clone                           Ipilimumab

Source/Isotype           Monoclonal Human IgG1 /κ

Application                 Flow Cytometry; Bioassay

Specificity                   Detects CTLA-4

Gene                            CTLA-4

Other Names              ALPS5, CD, CD152, CELIAC3, CTLA4, GRD4, GSE, IDDM12

Gene ID                       1493(human); G7PL88-1(Cynomolgus)

Background                CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. CTLA-4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA-4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. CTLA-4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

数据展示

/ueditor/image/20240527/1716775556306375/9bb994d4a5c8b0352ddc40613bd07dfc.png


/ueditor/image/20240527/1716775577580611/dbecf170a5cd6071570c5058f085261e.png


/ueditor/image/20240527/1716775599114006/6cf0348da4666ef1a394b494ac8429b7.png

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