当前位置:产品中心 > 抗体 > Biosimilar抗体 > TNF > Anti-H_TNFRSF1B(TNFR2) hIgG1 Antibody(UC2.3.8)
Anti-H_TNFRSF1B(TNFR2) hIgG1 Antibody(UC2.3.8)
基本信息

产品编号:GM-49245AB

产品名称:Anti-H_TNFRSF1B(TNFR2) hIgG1 Antibody(UC2.3.8)

目录价:询价


产品配图.jpg


规格货号

GM-49245AB-10         10 μg

GM-49245AB-100       100 μg

GM-49245AB-1000     1 mg

产品简介

Species Reactivity      Human

Specificity                   Detects human TNFRSF1B. It also detects cynomolgus TNFRSF1B.

Source/Isotype          Monoclonal human IgG1, κ

Other Names             p75; TBPII; TNFBR; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II

Gene ID                      7133(human), 102144224(cynomolgus)

Application                Flow cytometry: 1 μg-4 μg /1E6 cells;FC-Quality tested;Binding activation: 14 pg/mL-15 μg/mL

Background               Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as tumor necrosis factor receptor 2 (TNFR2) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necrosis factor receptor 1 (TNFR1), the extracellular region of TNFR2 consists of four cysteine-rich domains which allow for binding to TNFα. TNFR1 and TNFR2 possess different functions when bound to TNFα due to differences in their intracellular structures, such as TNFR2 lacking a death domain (DD). The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Storage                        Store at +4℃ short term (1-2 weeks). Store at -20℃ long term

Formulation                Phosphate-buffered solution, pH 7.2.




数据展示

/ueditor/image/20240515/1715762823664668/5dabab52ffa7c5df2768e3deffd994e3.png/ueditor/image/20240515/1715762827374264/1b0af8fa7a35d6b7815048ce959745a1.pngGM-49245AB-3.png


/ueditor/image/20240515/1715762923692846/a7b84f0ee98dcf00d67d2d4608abf388.png






当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-H_TNFRSF1B(TNFR2) hIgG1 Antibody(UC2.3.8)

Anti-H_TNFRSF1B(TNFR2) hIgG1 Antibody(UC2.3.8)
基本信息

产品编号:GM-49245AB

产品名称:Anti-H_TNFRSF1B(TNFR2) hIgG1 Antibody(UC2.3.8)

目录价:询价


产品配图.jpg


规格货号

GM-49245AB-10         10 μg

GM-49245AB-100       100 μg

GM-49245AB-1000     1 mg

产品简介

Species Reactivity      Human

Specificity                   Detects human TNFRSF1B. It also detects cynomolgus TNFRSF1B.

Source/Isotype          Monoclonal human IgG1, κ

Other Names             p75; TBPII; TNFBR; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II

Gene ID                      7133(human), 102144224(cynomolgus)

Application                Flow cytometry: 1 μg-4 μg /1E6 cells;FC-Quality tested;Binding activation: 14 pg/mL-15 μg/mL

Background               Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as tumor necrosis factor receptor 2 (TNFR2) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necrosis factor receptor 1 (TNFR1), the extracellular region of TNFR2 consists of four cysteine-rich domains which allow for binding to TNFα. TNFR1 and TNFR2 possess different functions when bound to TNFα due to differences in their intracellular structures, such as TNFR2 lacking a death domain (DD). The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Storage                        Store at +4℃ short term (1-2 weeks). Store at -20℃ long term

Formulation                Phosphate-buffered solution, pH 7.2.




数据展示

/ueditor/image/20240515/1715762823664668/5dabab52ffa7c5df2768e3deffd994e3.png/ueditor/image/20240515/1715762827374264/1b0af8fa7a35d6b7815048ce959745a1.pngGM-49245AB-3.png


/ueditor/image/20240515/1715762923692846/a7b84f0ee98dcf00d67d2d4608abf388.png






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