当前位置:产品中心 > 抗体 > Biosimilar抗体 > 细胞因子 > Anti-IL4R hIgG4 Reference Antibody (Dupbio)
Anti-IL4R hIgG4 Reference Antibody (Dupbio)
基本信息

产品编号:GM-87496MAB

产品名称:Anti-IL4R hIgG4 Reference Antibody (Dupbio)

目录价:询价

产品配图.jpg


规格货号

GM-87496MAB-1mg / 1 mg

GM-87496MAB-5mg / 5 mg

GM-87496MAB-25mg / 25 mg

GM-87496MAB-50mg / 50mg

GM-87496MAB-100mg / 100 mg



产品简介

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                           > 95% as determined by SDS-PAGE

Endotoxin                   < 1 EU/mg, determined by LAL gel clotting assay

Sterility                        0.2 μm Filtered

Target                            IL4R

Clone                             Dupilumab

Alternative Names   CD124; IL4RA; IL-4RA

Source/Isotype           Human IgG4(S228P), Kappa

Application                  /

Description                   The interleukin 4 receptor is a type I cytokine receptor. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among  T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.

Formulation               Phosphate-buffered solution, pH 7.4.


数据展示

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当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-IL4R hIgG4 Reference Antibody (Dupbio)

Anti-IL4R hIgG4 Reference Antibody (Dupbio)
基本信息

产品编号:GM-87496MAB

产品名称:Anti-IL4R hIgG4 Reference Antibody (Dupbio)

目录价:询价

产品配图.jpg


规格货号

GM-87496MAB-1mg / 1 mg

GM-87496MAB-5mg / 5 mg

GM-87496MAB-25mg / 25 mg

GM-87496MAB-50mg / 50mg

GM-87496MAB-100mg / 100 mg



产品简介

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                           > 95% as determined by SDS-PAGE

Endotoxin                   < 1 EU/mg, determined by LAL gel clotting assay

Sterility                        0.2 μm Filtered

Target                            IL4R

Clone                             Dupilumab

Alternative Names   CD124; IL4RA; IL-4RA

Source/Isotype           Human IgG4(S228P), Kappa

Application                  /

Description                   The interleukin 4 receptor is a type I cytokine receptor. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among  T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.

Formulation               Phosphate-buffered solution, pH 7.4.


数据展示

image.png

image.png

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