当前位置:产品中心 > 抗体 > 动物抗体 > Anti-Mouse Antibody > Anti-Mouse_PD1 mIgG1 Antibody
Anti-Mouse_PD1 mIgG1 Antibody
基本信息

产品编号:GM-28206AB

产品名称:Anti-Mouse_PD1 mIgG1 Antibody

目录价:询价

产品配图.jpg


规格货号

GM-28206AB-1mg          1mg

GM-28206AB-5mg          5mg   

GM-28206AB-25mg        25mg 

GM-28206AB-50mg        50mg 

GM-28206AB-100mg      100mg



产品简介

Expression System       CHO

Aggregation                < 5% as determined by SEC-HPLC

Purity                           >95% as determined by SDS-PAGE

Endotoxin                    <1 EU/mg, determined by LAL gel clotting assay

Sterility                         0.2 μm Filtered

Target                           PD1

Clone                            /

Alternative Names       PD-1; Pdc1; Ly101

Sourcellsotype             Monoclonal Mouse IgG1, κ

Application                  Flow cytometry; Binding activation: 1.5 ng/mL-100 μg/mL

Description                  The programmed cell death 1 protein (PD-1, PDCD1, CD279) is a member of the CD28 family of immunoreceptors that regulate T cell activation and immune responses. The PD-1 protein contains an extracellular Ig V domain, a transmembrane domain, and a cytoplasmic tail that includes an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM). PD-1 is activated by the cell surface ligands PD-L1 and PD-L2. Upon activation, PD-1 ITIM and ITSM phosphorylation leads to the recruitment of the protein tyrosine phosphatases SHP-1 and SHP-2, which suppress TCR signaling. In addition to activated T-cells, PD-1 is expressed in activated B-cells and monocytes, although its function in these cell types has not been fully characterized. The PD-1 pathway plays an important role in immune tolerance; however, research studies show that cancer cells often adopt this pathway to escape immune surveillance. Consequently, blockade of PD-1 and its ligands is proving to be a sound strategy for neoplastic intervention.

Formulation                 Phosphate-buffered solution, pH 7.2.



数据展示

image.png

image.png

image.png

image.png

当前位置:产品中心 > 抗体 > 动物抗体 > Anti-Mouse_PD1 mIgG1 Antibody

Anti-Mouse_PD1 mIgG1 Antibody
基本信息

产品编号:GM-28206AB

产品名称:Anti-Mouse_PD1 mIgG1 Antibody

目录价:询价

产品配图.jpg


规格货号

GM-28206AB-1mg          1mg

GM-28206AB-5mg          5mg   

GM-28206AB-25mg        25mg 

GM-28206AB-50mg        50mg 

GM-28206AB-100mg      100mg



产品简介

Expression System       CHO

Aggregation                < 5% as determined by SEC-HPLC

Purity                           >95% as determined by SDS-PAGE

Endotoxin                    <1 EU/mg, determined by LAL gel clotting assay

Sterility                         0.2 μm Filtered

Target                           PD1

Clone                            /

Alternative Names       PD-1; Pdc1; Ly101

Sourcellsotype             Monoclonal Mouse IgG1, κ

Application                  Flow cytometry; Binding activation: 1.5 ng/mL-100 μg/mL

Description                  The programmed cell death 1 protein (PD-1, PDCD1, CD279) is a member of the CD28 family of immunoreceptors that regulate T cell activation and immune responses. The PD-1 protein contains an extracellular Ig V domain, a transmembrane domain, and a cytoplasmic tail that includes an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM). PD-1 is activated by the cell surface ligands PD-L1 and PD-L2. Upon activation, PD-1 ITIM and ITSM phosphorylation leads to the recruitment of the protein tyrosine phosphatases SHP-1 and SHP-2, which suppress TCR signaling. In addition to activated T-cells, PD-1 is expressed in activated B-cells and monocytes, although its function in these cell types has not been fully characterized. The PD-1 pathway plays an important role in immune tolerance; however, research studies show that cancer cells often adopt this pathway to escape immune surveillance. Consequently, blockade of PD-1 and its ligands is proving to be a sound strategy for neoplastic intervention.

Formulation                 Phosphate-buffered solution, pH 7.2.



数据展示

image.png

image.png

image.png

image.png

Tel: 400-627-9288
留言咨询
重置
提交
客服
微信
电话
留言
留言咨询
重置
提交