当前位置:产品中心 > 抗体 > Biosimilar抗体 > 免疫检查点 > Anti-OX40L hIgG4 Reference Antibody (Amlbio)
Anti-OX40L hIgG4 Reference Antibody (Amlbio)
基本信息

产品编号:GM-87799MAB

产品名称:Anti-OX40L hIgG4 Reference Antibody (Amlbio)

目录价:询价

产品配图.jpg


规格货号

GM-87799MAB-1mg / 1 mg

GM-87799MAB-5mg / 5 mg

GM-87799MAB-25mg / 25 mg

GM-87799MAB-50mg / 50mg

GM-87799MAB-100mg / 100mg


产品简介

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                          > 95% as determined by SDS-PAGE

Endotoxin                   < 1 EU/mg, determined by LAL gel clotting assay

Sterility                        0.2 μm Filtered

Target                          OX40L

Clone                               Amlitelimab 

Alternative Names         GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B

Source/Isotype           Human IgG4 (S228P/ L235E), Kappa

Application                 /

Description                     OX40, also known as CD134 and Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels. OX40L binds to OX40 receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response due to its ability to enhance survival. OX40 also plays a crucial role in both Th1 and Th2 mediated reactions in vivo.

Formulation               Phosphate-buffered solution, pH 7.4.



数据展示

image.png

image.png

当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-OX40L hIgG4 Reference Antibody (Amlbio)

Anti-OX40L hIgG4 Reference Antibody (Amlbio)
基本信息

产品编号:GM-87799MAB

产品名称:Anti-OX40L hIgG4 Reference Antibody (Amlbio)

目录价:询价

产品配图.jpg


规格货号

GM-87799MAB-1mg / 1 mg

GM-87799MAB-5mg / 5 mg

GM-87799MAB-25mg / 25 mg

GM-87799MAB-50mg / 50mg

GM-87799MAB-100mg / 100mg


产品简介

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                          > 95% as determined by SDS-PAGE

Endotoxin                   < 1 EU/mg, determined by LAL gel clotting assay

Sterility                        0.2 μm Filtered

Target                          OX40L

Clone                               Amlitelimab 

Alternative Names         GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B

Source/Isotype           Human IgG4 (S228P/ L235E), Kappa

Application                 /

Description                     OX40, also known as CD134 and Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels. OX40L binds to OX40 receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response due to its ability to enhance survival. OX40 also plays a crucial role in both Th1 and Th2 mediated reactions in vivo.

Formulation               Phosphate-buffered solution, pH 7.4.



数据展示

image.png

image.png

Tel: 400-627-9288
留言咨询
重置
提交
客服
微信
电话
留言
留言咨询
重置
提交