当前位置:产品中心 > 抗体 > Biosimilar抗体 > 免疫检查点 > Anti-PD1 hIgG4 Antibody(Pembrolizumab)
Anti-PD1 hIgG4 Antibody(Pembrolizumab)
基本信息

产品编号:GM-52674AB

产品名称:Anti-PD1 hIgG4 Antibody(Pembrolizumab)

目录价:询价


产品配图.jpg

规格货号

GM-52674AB-10           10 μg

GM-52674AB-100         100 μg

GM-52674AB-1000       1mg

产品简介

Species Reactivity      Human; Cynomolgus

Clone                           Pembrolizumab

Source/Isotype           Monoclonal Human IgG4 /κ

Application                 Flow Cytometry

Specificity                   Detects PD1

Gene                            PD1

Other Names              CD279, PD-1, PDCD1, SLEB2, hPD-1, hPD-l, hSLE1

Gene ID                       5133(Human); 102123659 (Cynomolgus)

Background                The programmed cell death 1 protein (PD-1, PDCD1, CD279) is a member of the CD28 family of immunoreceptors that regulate T cell activation and immune responses. The PD-1 protein contains an extracellular Ig V domain, a transmembrane domain, and a cytoplasmic tail that includes an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM). PD-1 is activated by the cell surface ligands PD-L1 and PD-L2. Upon activation, PD-1 ITIM and ITSM phosphorylation leads to the recruitment of the protein tyrosine phosphatases SHP-1 and SHP-2, which suppress TCR signaling. In addition to activated T-cells, PD-1 is expressed in activated B-cells and monocytes, although its function in these cell types has not been fully characterized. The PD-1 pathway plays an important role in immune tolerance; however, research studies show that cancer cells often adopt this pathway to escape immune surveillance. Consequently, blockade of PD-1 and its ligands is proving to be a sound strategy for neoplastic intervention.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

数据展示

/ueditor/image/20240515/1715742413801913/da58a7388bdfb7e7c7847754bffe6183.png

/ueditor/image/20240515/1715742433118010/6dd8e1621e8f14975393452c6f648a22.png


/ueditor/image/20240515/1715742456653671/e11e6b73ac471295bf4d3cff64a2f5c7.png

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当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-PD1 hIgG4 Antibody(Pembrolizumab)

Anti-PD1 hIgG4 Antibody(Pembrolizumab)
基本信息

产品编号:GM-52674AB

产品名称:Anti-PD1 hIgG4 Antibody(Pembrolizumab)

目录价:询价


产品配图.jpg

规格货号

GM-52674AB-10           10 μg

GM-52674AB-100         100 μg

GM-52674AB-1000       1mg

产品简介

Species Reactivity      Human; Cynomolgus

Clone                           Pembrolizumab

Source/Isotype           Monoclonal Human IgG4 /κ

Application                 Flow Cytometry

Specificity                   Detects PD1

Gene                            PD1

Other Names              CD279, PD-1, PDCD1, SLEB2, hPD-1, hPD-l, hSLE1

Gene ID                       5133(Human); 102123659 (Cynomolgus)

Background                The programmed cell death 1 protein (PD-1, PDCD1, CD279) is a member of the CD28 family of immunoreceptors that regulate T cell activation and immune responses. The PD-1 protein contains an extracellular Ig V domain, a transmembrane domain, and a cytoplasmic tail that includes an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM). PD-1 is activated by the cell surface ligands PD-L1 and PD-L2. Upon activation, PD-1 ITIM and ITSM phosphorylation leads to the recruitment of the protein tyrosine phosphatases SHP-1 and SHP-2, which suppress TCR signaling. In addition to activated T-cells, PD-1 is expressed in activated B-cells and monocytes, although its function in these cell types has not been fully characterized. The PD-1 pathway plays an important role in immune tolerance; however, research studies show that cancer cells often adopt this pathway to escape immune surveillance. Consequently, blockade of PD-1 and its ligands is proving to be a sound strategy for neoplastic intervention.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

数据展示

/ueditor/image/20240515/1715742413801913/da58a7388bdfb7e7c7847754bffe6183.png

/ueditor/image/20240515/1715742433118010/6dd8e1621e8f14975393452c6f648a22.png


/ueditor/image/20240515/1715742456653671/e11e6b73ac471295bf4d3cff64a2f5c7.png

image.png

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