当前位置:产品中心 > 抗体 > Biosimilar抗体 > 免疫检查点 > Anti-mouse CTLA4 mIgG2a Antibody(9D9)
Anti-mouse CTLA4 mIgG2a Antibody(9D9)
基本信息

产品编号:GM-87752AB

产品名称:Anti-mouse CTLA4 mIgG2a Antibody(9D9)

目录价:询价


产品配图.jpg


规格货号

GM-87752AB-1mg           1mg

GM-87752AB-5mg           5mg

GM-87752AB-25mg         25mg

GM-87752AB-50mg         50mg

GM-87752AB-100mg       100mg


产品简介

Expression System     CHO

Aggregation                < 5% as determined by SEC-HPLC

Purity                           > 95% as determined by SDS-PAGE

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

Sterility                        0.2 μm Filtered

Target                          CLTA4

Clone                           9D9

Alternative Names     ALPS5, CD, CD152, CELIAC3, CTLA4, GRD4, GSE, IDDM12

Source/Isotype           Monoclonal Mouse mIgG2a, κ

Description                 CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. CTLA-4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA-4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. CTLA-4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4.

Formulation                Phosphate-buffered solution, pH 7.2.


数据展示

image.png


image.png

image.png

image.png

当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-mouse CTLA4 mIgG2a Antibody(9D9)

Anti-mouse CTLA4 mIgG2a Antibody(9D9)
基本信息

产品编号:GM-87752AB

产品名称:Anti-mouse CTLA4 mIgG2a Antibody(9D9)

目录价:询价


产品配图.jpg


规格货号

GM-87752AB-1mg           1mg

GM-87752AB-5mg           5mg

GM-87752AB-25mg         25mg

GM-87752AB-50mg         50mg

GM-87752AB-100mg       100mg


产品简介

Expression System     CHO

Aggregation                < 5% as determined by SEC-HPLC

Purity                           > 95% as determined by SDS-PAGE

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

Sterility                        0.2 μm Filtered

Target                          CLTA4

Clone                           9D9

Alternative Names     ALPS5, CD, CD152, CELIAC3, CTLA4, GRD4, GSE, IDDM12

Source/Isotype           Monoclonal Mouse mIgG2a, κ

Description                 CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. CTLA-4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA-4 binds CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA-4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. CTLA-4 is also found in regulatory T cells (Tregs) and contributes to their inhibitory function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4.

Formulation                Phosphate-buffered solution, pH 7.2.


数据展示

image.png


image.png

image.png

image.png

Tel: 400-627-9288
留言咨询
重置
提交
客服
微信
电话
留言
留言咨询
重置
提交