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Anti-H_LGR5 hIgG1 Antibody(18G7H6A3)
基本信息

产品编号:GM-46303AB

产品名称:Anti-H_LGR5 hIgG1 Antibody(18G7H6A3)

目录价:询价


产品配图.jpg


规格货号

GM-46303AB-10          10 μg

GM-46303AB-100         100 μg

GM-46303AB-1000       1mg


产品简介

Species Reactivity      Human; Cynomolgus

Clone                           18G7H6A3

Source/Isotype           Monoclonal Human IgG1 /κ

Application                 Flow cytometry

Specificity                   Detects LGR5

Gene                            LGR5

Other Names              FEX; HG38; GPR49; GPR67; GRP49

Gene ID                       8549

Background                The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. Although its ligand remains elusive, it has been shown that costimulation with R-spondin 1 and Wnt-3a induce increased internalization of LGR5. LGR5 also cointernalizes with LRP6 and FZD5 via a clathrin-dependent pathway to form a ternary complex upon Wnt ligand binding. Moreover, the rapid cointernalization of LRP6 by LGR5 induces faster rates of degradation for the former. It has been shown that the C-terminal region of LGR5 is crucial for both dynamic internalization and degradation to occur, although C-terminal truncation does not inhibit LRP6 interaction and internalization, but rather, heightens receptor activity. Thus, only the initial interaction with its unknown ligand and other membrane bound receptors is crucial in its role in Wnt signalling and not the internalization itself.[10] LGR5 is crucial during embryogenesis as LGR null studies in mice incurred 100% neonatal mortality accompanied by several craniofacial distortions such as ankyloglossia and gastrointestinal dilation.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay


数据展示

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当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-H_LGR5 hIgG1 Antibody(18G7H6A3)

Anti-H_LGR5 hIgG1 Antibody(18G7H6A3)
基本信息

产品编号:GM-46303AB

产品名称:Anti-H_LGR5 hIgG1 Antibody(18G7H6A3)

目录价:询价


产品配图.jpg


规格货号

GM-46303AB-10          10 μg

GM-46303AB-100         100 μg

GM-46303AB-1000       1mg


产品简介

Species Reactivity      Human; Cynomolgus

Clone                           18G7H6A3

Source/Isotype           Monoclonal Human IgG1 /κ

Application                 Flow cytometry

Specificity                   Detects LGR5

Gene                            LGR5

Other Names              FEX; HG38; GPR49; GPR67; GRP49

Gene ID                       8549

Background                The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. Although its ligand remains elusive, it has been shown that costimulation with R-spondin 1 and Wnt-3a induce increased internalization of LGR5. LGR5 also cointernalizes with LRP6 and FZD5 via a clathrin-dependent pathway to form a ternary complex upon Wnt ligand binding. Moreover, the rapid cointernalization of LRP6 by LGR5 induces faster rates of degradation for the former. It has been shown that the C-terminal region of LGR5 is crucial for both dynamic internalization and degradation to occur, although C-terminal truncation does not inhibit LRP6 interaction and internalization, but rather, heightens receptor activity. Thus, only the initial interaction with its unknown ligand and other membrane bound receptors is crucial in its role in Wnt signalling and not the internalization itself.[10] LGR5 is crucial during embryogenesis as LGR null studies in mice incurred 100% neonatal mortality accompanied by several craniofacial distortions such as ankyloglossia and gastrointestinal dilation.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay


数据展示

image.png

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