当前位置:产品中心 > 抗体 > Biosimilar抗体 > 细胞因子 > Anti-IL-17A hIgG1 Antibody(Secukinumab)
Anti-IL-17A hIgG1 Antibody(Secukinumab)
基本信息

产品编号:GM-27267AB

产品名称:Anti-IL-17A hIgG1 Antibody(Secukinumab) 

目录价:询价


产品配图.jpg


规格货号

GM-27267AB-10           10 μg

GM-27267AB-100         100 μg

GM-27267AB-1000       1mg


产品简介

Species Reactivity      Human

Clone                           Secukinumab

Source/Isotype           Monoclonal Human IgG1/κ

Application                 Block assay

Specificity                   Detects IL-17A

Gene                            IL-17A

Other Names              CTLA-8, CTLA8, IL17A, IL17, ILA17

Gene ID                       3605

Background                This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. 

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay




数据展示

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当前位置:产品中心 > 抗体 > Biosimilar抗体 > Anti-IL-17A hIgG1 Antibody(Secukinumab)

Anti-IL-17A hIgG1 Antibody(Secukinumab)
基本信息

产品编号:GM-27267AB

产品名称:Anti-IL-17A hIgG1 Antibody(Secukinumab) 

目录价:询价


产品配图.jpg


规格货号

GM-27267AB-10           10 μg

GM-27267AB-100         100 μg

GM-27267AB-1000       1mg


产品简介

Species Reactivity      Human

Clone                           Secukinumab

Source/Isotype           Monoclonal Human IgG1/κ

Application                 Block assay

Specificity                   Detects IL-17A

Gene                            IL-17A

Other Names              CTLA-8, CTLA8, IL17A, IL17, ILA17

Gene ID                       3605

Background                This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. 

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay




数据展示

image.png

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