当前位置:产品中心 > 细胞系 > Kinase > HER2(ERBB2) > H_HER2 HER4 Reporter HEK-293 Cell Line
H_HER2 HER4 Reporter HEK-293 Cell Line
基本信息

产品编号:GM-C34194

产品名称:H_HER2 HER4 Reporter HEK-293 Cell Line

目录价:询价

产品配图.jpg

细胞培养、冻存、复苏试剂准备

生长培养基:DMEM+10% FBS+1% P.S+4 μg/mL Blasticidin+400 μg/mL G418+125 μg/mL Hygromycin+0.75 μg/mL Puromycin

细胞冻存液:90% FBS+10% DMSO

Assay Buffer:DMEM+1% FBS+1% P.S

产品简介

HER2(人类表皮生长因子受体2型)和HER4(人类表皮生长因子受体4型)都是表皮生长因子受体家族的成员。在癌症,尤其是乳腺癌的研究中,HER2因其在某些肿瘤中过度表达而受到广泛关注。


HER2受体的过表达与细胞增殖、存活及侵袭性增强相关。HER2阳性的乳腺癌通常预后较差,但针对HER2的靶向治疗(如曲妥珠单抗)显著改善了患者的治疗效果。HER4在临床上相对较少被研究。它的作用相对复杂,可能在某些情况下起到抗肿瘤的作用,但在其他情况下也可能促进肿瘤发生。同时靶向HER2和HER4可能帮助克服单靶点治疗的耐药性,提高治疗效果。尤其在HER2阳性且HER4也表达的肿瘤中,双靶点治疗可能更具意义。


吉满生物的H_HER2 HER4 Reporter HEK-293 Cell Line是一种Luciferase报告基因细胞系,配体结合HER2、HER4受体后,可以激活下游信号通路,随后通过测定荧光信号确定荧光素酶的表达,间接评估配体对信号通路的影响程度,从而达到判断配体结合受体的验证效果。

数据展示
相关产品
HER3(ERBB3)
Cynomolgus_ERBB3(HER3) CHO-K1 Cell Line Cynomolgus_ERBB3(HER3) HEK-293 Cell Line H_ERBB3(HER3) CHO-K1 Cell Line
H_ERBB3(HER3) HEK-293 Cell LineH_ERBB3(HER3) MC38 Cell LineMouse_HER3(ERBB3) CHO-K1 Cell Line
Anti-ERBB3(HER3) hIgG1 Reference Antibody(Patribio)Anti-H_ERBB3(HER3) hIgG1 Antibody(Barecetamab)Anti-H_HER3 hIgG1 Antibody(Patritumab)
Human HER3 Protein; His Tag

NECTIN4
Cynomolgus_Nectin4 CHO-K1 Cell LineH_NECTIN4 CT26 Cell LineH_NECTIN4 HEK-293 Cell Line
H_NECTIN4 LLC1 Cell LineH_NECTIN4 MC38 Cell LineH_NECTIN4(nectin-4) CHO-K1 Cell Line
Mouse_NECTIN4 CHO-K1 Cell Line

Anti-H_Nectin4 hIgG1 Antibody(Enfortumab)Anti-Nectin4 hIgG1 Reference Antibody (Enfobio)
Biotinylated Cynomolgus Nectin-4 Protein; His-Avi TagBiotinylated Human Nectin-4 Protein; His-Avi TagBiotinylated Mouse Nectin-4 Protein; His-Avi Tag
Cynomolgus Nectin-4 Protein; His TagHuman Nectin-4 Protein; His Tag
SLC39A6(LIV1)
Cynomolgus_SLC39A6 CHO-K1 Cell LineH_SLC39A6 CHO-K1 Cell LineH_SLC39A6 HEK-293 Cell Line
H_SLC39A6 LLC1 Cell LineH_SLC39A6 MC38 Cell Line
Anti-H_SLC39A6 hIgG1 Antibody(Ladiratuzumab)Anti-SLC39A6 hIgG1 Reference Antibody (Ladbio)
Anti-SLC39A6-MMAE ADC(Dar4)[Ladiratuzumab vedotin]

HER2(ERBB2)
Cynomolgus_HER2(ERBB2) CHO-K1 Cell LineH_HER2 EMT6 Cell LineH_HER2 HER3 MC38 Cell Line
H_HER2 MCF-7 Cell LineH_HER2(ERBB2) CHO-K1 Cell LineH_HER2(ERBB2) CT26 Cell Line
H_HER2(ERBB2) LLC1 Cell LineH_HER2(ERBB2) MC38 Cell Line
Anti-H_HER2 hIgG1 Antibody(Margetuximab)Anti-HER2 hIgG1 Reference Antibody(Marbio)Anti-HER2 hIgG1 Reference Antibody(Trasbio)
Anti-HER2-DM1 ADC(Dar4)[Trastuzumab emtansine,T-DM1]Anti-HER2-DXD ADC(Dar8)[Trastuzumab Deruxtecan]
Cynomolgus HER2 Protein; His TagHuman HER2 Protein; His Tag
ADC Related Product
Anti-DXD Mouse IgG1 Antibody (23E21C5)Anti-DXD Mouse IgG1 Antibody (4A5A12)Anti-Dxd Mouse IgG2a Antibody (17D6A4)
Anti-Eribulin Mouse IgG2a Antibody (10F8G4)Anti-MMAE Mouse IgG1 Antibody (11C10E3)Anti-MMAE Mouse IgG2a Antibody (17A1K11)
Anti-MMAE Mouse IgG2a Antibody (8F6A3)Mouse anti Human IgG-MMAE(Dar4)
Human IgG1 Isotype-DXD (Dar8)Human IgG1 Isotype-Eribulin (Dar4)Human IgG1 Isotype-MMAE (Dar4)
Recombinant DT3C Protein


当前位置:产品中心 > 细胞系 > Kinase > HER2(ERBB2) > H_HER2 HER4 Reporter HEK-293 Cell Line

H_HER2 HER4 Reporter HEK-293 Cell Line
基本信息

产品编号:GM-C34194

产品名称:H_HER2 HER4 Reporter HEK-293 Cell Line

目录价:询价

产品配图.jpg

细胞培养、冻存、复苏试剂准备

生长培养基:DMEM+10% FBS+1% P.S+4 μg/mL Blasticidin+400 μg/mL G418+125 μg/mL Hygromycin+0.75 μg/mL Puromycin

细胞冻存液:90% FBS+10% DMSO

Assay Buffer:DMEM+1% FBS+1% P.S

产品简介

HER2(人类表皮生长因子受体2型)和HER4(人类表皮生长因子受体4型)都是表皮生长因子受体家族的成员。在癌症,尤其是乳腺癌的研究中,HER2因其在某些肿瘤中过度表达而受到广泛关注。


HER2受体的过表达与细胞增殖、存活及侵袭性增强相关。HER2阳性的乳腺癌通常预后较差,但针对HER2的靶向治疗(如曲妥珠单抗)显著改善了患者的治疗效果。HER4在临床上相对较少被研究。它的作用相对复杂,可能在某些情况下起到抗肿瘤的作用,但在其他情况下也可能促进肿瘤发生。同时靶向HER2和HER4可能帮助克服单靶点治疗的耐药性,提高治疗效果。尤其在HER2阳性且HER4也表达的肿瘤中,双靶点治疗可能更具意义。


吉满生物的H_HER2 HER4 Reporter HEK-293 Cell Line是一种Luciferase报告基因细胞系,配体结合HER2、HER4受体后,可以激活下游信号通路,随后通过测定荧光信号确定荧光素酶的表达,间接评估配体对信号通路的影响程度,从而达到判断配体结合受体的验证效果。

数据展示
相关产品
HER3(ERBB3)
Cynomolgus_ERBB3(HER3) CHO-K1 Cell Line Cynomolgus_ERBB3(HER3) HEK-293 Cell Line H_ERBB3(HER3) CHO-K1 Cell Line
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NECTIN4
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Mouse_NECTIN4 CHO-K1 Cell Line

Anti-H_Nectin4 hIgG1 Antibody(Enfortumab)Anti-Nectin4 hIgG1 Reference Antibody (Enfobio)
Biotinylated Cynomolgus Nectin-4 Protein; His-Avi TagBiotinylated Human Nectin-4 Protein; His-Avi TagBiotinylated Mouse Nectin-4 Protein; His-Avi Tag
Cynomolgus Nectin-4 Protein; His TagHuman Nectin-4 Protein; His Tag
SLC39A6(LIV1)
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Anti-H_SLC39A6 hIgG1 Antibody(Ladiratuzumab)Anti-SLC39A6 hIgG1 Reference Antibody (Ladbio)
Anti-SLC39A6-MMAE ADC(Dar4)[Ladiratuzumab vedotin]

HER2(ERBB2)
Cynomolgus_HER2(ERBB2) CHO-K1 Cell LineH_HER2 EMT6 Cell LineH_HER2 HER3 MC38 Cell Line
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Anti-H_HER2 hIgG1 Antibody(Margetuximab)Anti-HER2 hIgG1 Reference Antibody(Marbio)Anti-HER2 hIgG1 Reference Antibody(Trasbio)
Anti-HER2-DM1 ADC(Dar4)[Trastuzumab emtansine,T-DM1]Anti-HER2-DXD ADC(Dar8)[Trastuzumab Deruxtecan]
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Anti-Eribulin Mouse IgG2a Antibody (10F8G4)Anti-MMAE Mouse IgG1 Antibody (11C10E3)Anti-MMAE Mouse IgG2a Antibody (17A1K11)
Anti-MMAE Mouse IgG2a Antibody (8F6A3)Mouse anti Human IgG-MMAE(Dar4)
Human IgG1 Isotype-DXD (Dar8)Human IgG1 Isotype-Eribulin (Dar4)Human IgG1 Isotype-MMAE (Dar4)
Recombinant DT3C Protein


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