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Activin A Reporter Cell Line
基本信息

产品编号:GM-C26082

产品名称:Activin A Reporter Cell Line

目录价:询价

GM-C26082信号通路图.png

细胞培养、冻存、复苏试剂准备

生长培养基:DMEM+10% FBS+1% P.S+4 μg/mL Blasticidin

细胞冻存液:90% FBS+10% DMSO

Assay Buffer:DMEM+1% FBS+1% P.S


产品简介

ActRIIA (ACVR2A)和ActRIIB(ACVR2B)是转化生长因子β(TGF-β)受体家族的成员,是包括活化素A(Activin A)和活化素B(Activin B)及BMP7、BMP9、BMP10、GDF1、GDF8(myostatin)、 GDF11和Nodal在内的其他TGF-β家族成员的II型号受体。 ALK4和ALK7分别是活化素A和活化素B的主要I型TGF-β受体家族成员。Bimagrumab 是一种人源单克隆抗体,可阻断激活素 II 型受体 (ActRII),从而对骨骼肌生长进行调节。


吉满生物Activin A Reporter Cell Line细胞系是基于Activin A作为激动剂的一种Luciferase报告基因细胞系(此细胞只用于Activn A活性检测;不区分ACVR2A、ACVR2B)。当Activin A与受体结合,激活信号通路,从而激活荧光素酶(Luciferase)的表达,Luciferase读值即代表信号通路的激活效果。另外,此激活效果也可被阻断型抗体阻断,例如Bimagrumab,因此可用于相关药物的体外评价效果。

数据展示
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当前位置:产品中心 > 细胞系 > 细胞因子 > TGF-β > Activin A Reporter Cell Line

Activin A Reporter Cell Line
基本信息

产品编号:GM-C26082

产品名称:Activin A Reporter Cell Line

目录价:询价

GM-C26082信号通路图.png

细胞培养、冻存、复苏试剂准备

生长培养基:DMEM+10% FBS+1% P.S+4 μg/mL Blasticidin

细胞冻存液:90% FBS+10% DMSO

Assay Buffer:DMEM+1% FBS+1% P.S


产品简介

ActRIIA (ACVR2A)和ActRIIB(ACVR2B)是转化生长因子β(TGF-β)受体家族的成员,是包括活化素A(Activin A)和活化素B(Activin B)及BMP7、BMP9、BMP10、GDF1、GDF8(myostatin)、 GDF11和Nodal在内的其他TGF-β家族成员的II型号受体。 ALK4和ALK7分别是活化素A和活化素B的主要I型TGF-β受体家族成员。Bimagrumab 是一种人源单克隆抗体,可阻断激活素 II 型受体 (ActRII),从而对骨骼肌生长进行调节。


吉满生物Activin A Reporter Cell Line细胞系是基于Activin A作为激动剂的一种Luciferase报告基因细胞系(此细胞只用于Activn A活性检测;不区分ACVR2A、ACVR2B)。当Activin A与受体结合,激活信号通路,从而激活荧光素酶(Luciferase)的表达,Luciferase读值即代表信号通路的激活效果。另外,此激活效果也可被阻断型抗体阻断,例如Bimagrumab,因此可用于相关药物的体外评价效果。

数据展示
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