当前位置:产品中心 > 细胞系 > 细胞因子 > TGF-β > H_ACVR2A Reporter Cell Line
H_ACVR2A Reporter Cell Line
基本信息

产品编号:GM-C28074

产品名称:H_ACVR2A Reporter Cell Line

目录价:询价

GM-C28074信号通路图.png

细胞培养、冻存、复苏试剂准备

生长培养基:DMEM+10% FBS+1% P.S+125 μg/mL Hygromycin+400 μg/mL G418

细胞冻存液:90% FBS+10% DMSO

Assay Buffer:DMEM+10% FBS+1% P.S

注意:此细胞对抗生素非常敏感,应使用吉满配套的细胞生长培养基

产品简介

ActRIIA (ACVR2A)和ActRIIB(ACVR2B)是转化生长因子β(TGF-β)受体家族的成员,是包括活化素A(Activin A)和活化素B(Activin B)及BMP7、BMP9、BMP10、GDF1、GDF8(myostatin)、 GDF11和Nodal在内的其他TGF-β家族成员的II型号受体。 ALK4和ALK7分别是活化素A和活化素B的主要I型TGF-β受体家族成员。Bimagrumab 是一种人源单克隆抗体,可阻断激活素 II 型受体 (ActRII),从而对骨骼肌生长进行调节。据研究发现,Bimagrumab与ActRIIB、ActRIIA均具有亲和力,但与ActRIIB的亲和力至少比与ActRIIA强200倍。


吉满生物H_ACVR2A Reporter Cell Line是一种Luciferase报告基因细胞系。在吉满生物 Activin A Reporter Cell Line(Genomeditech/GM-C26082)的基础上,将 ACVR2B基因敲除,因此GDF8等蛋白只能结合ACVR2A激活下游信号通路。通过加入特定的拮抗型抗体,阻断由此激活的下游信号通路,随后,通过测定荧光信号确定荧光素酶(Luciferase)的表达,间接评估拮抗剂对信号通路的影响程度,因此,此细胞可便捷、灵敏、特异性的筛选和验证靶向ActRIIA的拮抗型药物。

数据展示
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Anti-CALCRL RAMP1 hIgG2 Antibody(Erenumab)

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ACVR2A:ACTRIIB:Active A
ACVR2A KO HEK-293 Cell LineActivin A Reporter Cell LineH_ACVR2B Reporter Cell Line
ACVR2B KO HEK-293 Cell LineH_ACVR2A HEK-293(ACVR2B KO) Cell LineH_ACVR2B CHO-K1 Cell Line
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Anti-ACVR2A/B hIgG1 Antibody(D-03)Anti-ACVR2B hIgG1 Antibody(Bimagrumab)Anti-ACVR2B hIgG1 Antibody(Fab-17G05)
Anti-ACVR2B mIgG2a Antibody(Bimagrumab)Anti-H_ACVR2B hIgG1 Reference Antibody(Bimbio)
Biotinylated Human ACVR2B Protein; His-Avi TagBiotinylated Mouse ACVR2A Protein; His-Avi TagBiotinylated Mouse ACVR2B Protein; His-Avi Tag
Human Activin A Protein; His TagHuman Activin B Protein; His TagHuman ACVR2A Protein; hFc Tag
Human ACVR2A Protein; His TagHuman ACVR2B Protein; hFc TagHuman ACVR2B Protein; His Tag
Human ACVR2B Protein; His-Avi TagHuman/Mouse/Rat GDF-8 Protein; His TagMouse ACVR2B Protein; His Tag
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当前位置:产品中心 > 细胞系 > 细胞因子 > TGF-β > H_ACVR2A Reporter Cell Line

H_ACVR2A Reporter Cell Line
基本信息

产品编号:GM-C28074

产品名称:H_ACVR2A Reporter Cell Line

目录价:询价

GM-C28074信号通路图.png

细胞培养、冻存、复苏试剂准备

生长培养基:DMEM+10% FBS+1% P.S+125 μg/mL Hygromycin+400 μg/mL G418

细胞冻存液:90% FBS+10% DMSO

Assay Buffer:DMEM+10% FBS+1% P.S

注意:此细胞对抗生素非常敏感,应使用吉满配套的细胞生长培养基

产品简介

ActRIIA (ACVR2A)和ActRIIB(ACVR2B)是转化生长因子β(TGF-β)受体家族的成员,是包括活化素A(Activin A)和活化素B(Activin B)及BMP7、BMP9、BMP10、GDF1、GDF8(myostatin)、 GDF11和Nodal在内的其他TGF-β家族成员的II型号受体。 ALK4和ALK7分别是活化素A和活化素B的主要I型TGF-β受体家族成员。Bimagrumab 是一种人源单克隆抗体,可阻断激活素 II 型受体 (ActRII),从而对骨骼肌生长进行调节。据研究发现,Bimagrumab与ActRIIB、ActRIIA均具有亲和力,但与ActRIIB的亲和力至少比与ActRIIA强200倍。


吉满生物H_ACVR2A Reporter Cell Line是一种Luciferase报告基因细胞系。在吉满生物 Activin A Reporter Cell Line(Genomeditech/GM-C26082)的基础上,将 ACVR2B基因敲除,因此GDF8等蛋白只能结合ACVR2A激活下游信号通路。通过加入特定的拮抗型抗体,阻断由此激活的下游信号通路,随后,通过测定荧光信号确定荧光素酶(Luciferase)的表达,间接评估拮抗剂对信号通路的影响程度,因此,此细胞可便捷、灵敏、特异性的筛选和验证靶向ActRIIA的拮抗型药物。

数据展示
相关产品
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H_GCGR Reporter CHO-K1 Cell LineH_GCGR Reporter HEK-293 Cell LineH_GCGR Reporter HEK-293 DDX35TM Cell Line
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Anti-CALCRL RAMP1 hIgG2 Antibody(Erenumab)

GIP:GIPR
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Anti-H_GIPR hIgG1 Antibody(AMG-133)

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AMY:CALCR RAMP
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